慢病毒系列|助力肿瘤研究成果—结直肠癌/肝癌/胃癌/肺癌/乳腺癌/胰腺癌
和元生物用心做科研 让基因递送触手可及
和元生物一直致力于病毒载体的研制服务,有专业的研发团队专注于病毒载体及包装系统的升级改造。追求更有效、更安全、更真实、更稳定,提供高品质的产品。
自主研发获批专利的Vpack慢病毒包装系统,全面解决病毒不出毒和滴度低的问题,使lncRNA表达更精确,助力肿瘤热点研究。
小编精心整理了使用和元生物慢病毒(LV)产品近期发表的高质量文章,希望可以为您的科研之路保驾护航。
结直肠癌
1
IF:38.104 Signal Transduct Target Ther
标题:Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling(2021年,代谢 基因机制)
作者及单位:上海交通大学医学院附属仁济医院 房静远
细胞/动物:DLD-1(人结直肠腺癌上皮细胞)/ BALB/c裸鼠
和元生物服务:LV-shlncSLCC1/LV-HK2/LV-NC(干扰 过表达)
原文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892549/pdf/41392_2020_Article_446.pdf
2
IF:33.883 Gastroenterology
标题:Enterotoxigenic Bacteroides fragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p(2021年,外泌体 肠炎 结直肠癌)
作者及单位:上海交通大学医学院附属仁济医院 洪洁
细胞:HCT116/SW480(人结直肠癌细胞)
和元生物服务:LV-miR-149-3p/LV-NC/Ad-miR-149-3p/Ad-NC(过表达)
原文链接:https://www.sciencedirect.com/science/article/abs/pii/S0016508521033412
3
IF:38.104 Signal Transduct Target Ther
标题:Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis(2022年,代谢酶 化疗敏感性)
作者及单位:中山大学 徐瑞华(邱妙珍)
细胞:HCT116/DLD1(人结直肠癌细胞/人结直肠腺癌上皮细胞)
和元生物服务:LV-shNFS1/LV-NC(干扰)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882671/pdf/41392_2022_Article_889.pdf
4
IF:12.771 J Biomed Sci
标题:SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling(2022年,DNA甲基化 信号通路)
作者及单位:无锡第四人民医院 黄朝晖
细胞:HT29/SW480(人结直肠癌细胞)
和元生物服务:LV-shSLCO4A1-AS1 /LV- SLCO4A1-AS1 /LV-NC(干扰 过表达)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762969/pdf/12929_2022_Article_789.pdf
5
IF:12.658 J Exp Clin Cancer Res
标题:Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK(2021年,非编码cicrRNA 基因机制)
作者及单位:南京医科大学第一附属医院 孙跃明
细胞:LoVo/DLD-1/RKO/HCT 116(人结直肠癌细胞)
和元生物服务:LV-shcirc-GALNT16/LV-circ-GALNT16/LV-NC(干扰 过表达)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400830/pdf/13046_2021_Article_2074.pdf
更多客户文章:
[1]. FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis. Oncogene. 2021 Aug;40(33):5168-5181.
[2]. KIAA1429 is a potential prognostic marker in colorectal cancer by promoting the proliferation via downregulating WEE1 expression in an m6A-independent manner. Oncogene. 2022 Jan;41(5):692-703.
[3]. Nuclear PD-L1 promotes cell cycle progression of BRAF-mutated colorectal cancer by inhibiting THRAP3. Cancer Lett. 2022 Feb 28;527:127-139.
[4]. UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer. Cell Death Dis. 2021 May 21;12(6):519.
[5]. Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer. Cell Death Dis. 2021 Feb 15;12(2):183.
[6]. A MiR-532–3p suppresses cell proliferation, migration and invasion of colon adenocarcinoma via targeting FJX1. Pathol Res Pract. 2022 Apr;232:153835.
[7]. Quadruple-editing of the MAPK and PI3K pathways effectively blocks the progression of KRAS-mutated colorectal cancer cells. Cancer Sci. 2021 Sep;112(9):3895-3910.
[8]. Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity. Am J Cancer Res. 2021 Jun 15;11(6):3039-3054.
[9]. The lncRNA XIST/miR-125b-2-3p axis modulates cell proliferation and chemotherapeutic sensitivity via targeting Wee1 in colorectal cancer. Cancer Med. 2021 Apr;10(7):2423-2441.
[10]. RUNX1 regulates the proliferation and chemoresistance of colorectal cancer through the Hedgehog signaling pathway. J Cancer. 2021 Sep 3;12(21):6363-6371.
[11]. N6‑methyladenosine upregulates miR‑181d‑5p in exosomes derived from cancer‑associated fibroblasts to inhibit 5‑FU sensitivity by targeting NCALD in colorectal cancer. Int J Oncol. 2022 Feb;60(2):14.
肝癌
1
IF:31.373 Cell Metab
标题:NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion(2021年,肿瘤代谢与免疫)
作者及单位:海军军医大学 王红阳
细胞:Hepa1–6(小鼠肝癌细胞)
和元生物服务:LV-shNampt/LV-shCd274/LV-NC(干扰)
原文链接:https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(20)30554-4
2
IF:9.995 Cell Rep
标题:Androgens drive sexual dimorphism in liver metastasis by promoting hepatic accumulation of neutrophils(2022年,肝癌转移 信号通路)
作者及单位:海军军医大学 王红阳
细胞:B16F10/MC38(小鼠黑色素瘤高转移细胞/小鼠结肠癌细胞)
和元生物服务:LV-GFP/Luc(荧光蛋白/荧光素酶)
原文链接:https://www.cell.com/cell-reports/pdfExtended/S2211-1247(22)00773-2
3
IF:9.756 Cancer Lett
标题:MTDH antisense oligonucleotides reshape the immunosuppressive tumor microenvironment to sensitize Hepatocellular Carcinoma to immune(2022年,肿瘤微环境)
作者及单位:复旦大学 代智
细胞:Hepa1-6(小鼠肝癌细胞)
和元生物服务:LV-shMTDH/LV-NC, siMTDH/CEBPB/IRF1/OCT1/GATA1/NF1/LEF1(干扰)
原文链接:
https://www.sciencedirect.com/science/article/abs/pii/S0304383522002348?via%3Dihub
4
IF:9.756 Cancer Lett
标题:Down-regulation of circPTTG1IP induces hepatocellular carcinoma development via miR-16-5p/RNF125/JAK1 axis(2022年,信号通路)
作者及单位:扬州大学临床医学院 张弛
细胞:MHCC-97H/PLC(人肝癌细胞)
和元生物服务:LV-shRNF125/LV-miR-16-5p/LV-NC(干扰 过表达)
原文链接:
https://reader.elsevier.com/reader/sd/pii/S0304383522002622?token=57373C9956227317C84693CB25B95661CCFD5467D89B7B1F6C85CD166DD2B55AA06B84601F98C84A0C9A88DE0FAC8243&originRegion=eu-west-1&originCreation=20221018034107
5
IF:9.685 Cell Death Dis
标题:Downregulation of MUC15 by miR-183-5p. 1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2(2022年,肝癌转移 信号通路)
作者及单位:海军军医大学 王若愚
细胞:Hep3B/Huh7(人肝癌细胞)
和元生物服务:LV-FLAG-MUC15/LV-NC(过表达)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891362/pdf/41419_2022_Article_4652.pdf
更多客户文章:
[1]. Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin. Cell Death Dis. 2021 Nov 18;12(12):1093.
[2]. Lysophosphatidylcholine acyltransferase 1 promotes epithelialmesenchymal transition of hepatocellular carcinoma via the Wnt/ b-catenin signaling. Ann Hepatol. 2022 May-Jun;27(3):100680.
[3]. Circular RNA circUBE2J2 acts as the sponge of microRNA-370-5P to suppress hepatocellular carcinoma progression. Cell Death Dis. 2021 Oct 22;12(11):985.
[4]. Exploring the Prognostic Value, Immune Implication and Biological Function of H2AFY Gene in Hepatocellular Carcinoma. Front Immunol. 2021 Nov 24;12:723293.
[5]. BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways. Cell Death Dis. 2021 Jan 11;12(1):63.
[6]. KIF18B as a regulator in tumor microenvironment accelerates tumor progression and triggers poor outcome in hepatocellular carcinoma. Int J Biochem Cell Biol. 2021 Aug;137:106037.
[7]. Long noncoding RNA Gas5 induces cell apoptosis and inhibits tumor growth via activating the CHOP‐dependent endoplasmic reticulum stress pathway. J Cell Biochem. 2022 Feb;123(2):231-247.
[8]. Hepatitis B virus x gene‑downregulated growth‑arrest specific 5 inhibits the cell viability and invasion of hepatocellular carcinoma cell lines by activating Y-box-binding protein 1/p21 signaling. J Cell Commun Signal. 2022 Jun;16(2):179-190.
[9]. Development of digital organ‑on‑a‑chip to assess hepatotoxicity and extracellular vesicle‑based anti‑liver cancer immunotherapy. Bio-Design and Manufacturing. 2022 volume 5, pages 437–450.
[10]. Circular RNA circ_0008934 promotes hepatocellular carcinoma growth and metastasis through modulating miR‑1305/TMTC3 axis. Hum Cell. 2022 Mar;35(2):498-510.
胃癌
1
IF:13.391 Autophagy
标题:Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer
via autophagy activation(2021年,非编码LncRNA 自噬 耐药)
作者及单位:南方医科大学 廖旺军
细胞:MGC803/MKN45(人胃癌细胞)
和元生物服务:LV-EIF3J-DT/LV-NC(过表达)
原文链接:https://sci-hub.st/10.1080/15548627.2021.1901204
2
IF:12.658 J Exp Clin Cancer Res
标题:HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis(2021年,肿瘤转移)
作者及单位:上海交通大学医学院附属第一人民医院 周崇治
细胞:AGS/BGC823(人胃腺癌细胞)
和元生物服务:LV-shMETTL3/LV-METTL3/LV-NC(干扰 过表达)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874610/pdf/13046_2021_Article_1859.pdf
3
IF:11.6 Theranostics
标题:PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1(2021年,去泛素化)
作者及单位:华中科技大学同济医学院附属协和医院 舒晓刚
细胞:AGS(人胃腺癌细胞)
和元生物服务:LV-Flag -PLAGL2/LV-NC(过表达)
原文链接:https://www.thno.org/v11p0700.pdf
4
IF:8.554 Clin Transl Med
标题:Apolipoprotein C-II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway(2021年,胃癌腹膜转移 信号通路)
作者及单位:南京大学附属鼓楼医院 管文贤
细胞:AGS(人胃腺癌细胞)
和元生物服务:LV-shCD36/LV-APOC2/LV-CD36/LV-NC(干扰 过表达)
原文链接:https://sci-hub.st/10.1002/ctm2.522
5
IF:7.109 Cell Death Discov
标题:RUNDC3A regulates SNAP25-mediated chemotherapy resistance by binding AKT in gastric neuroendocrine carcinoma(GNEC)(2022年,胃神经内分泌癌 化疗耐药)
作者及单位:澳门大学 Hang Fai Kwok
细胞:AGS(人胃腺癌细胞)
和元生物服务:LV-shSNAP25/LV-shRUNDC3A/LV-SNAP25/LV-RUNDC3A/LV-NC(干扰 过表达)
原文链接:https://www.nature.com/articles/s41420-022-01084-4#Sec9
更多客户文章:
[1]. CircTMC5 promotes gastric cancer progression and metastasis by targeting miR‑361‑3p/RABL6. Gastric Cancer. 2022 Jan;25(1):64-82.
[2]. YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis. Int J Biol Sci. 2021 Apr 12;17(7):1629-1643.
[3]. Long Noncoding RNA SNHG12 Promotes Gastric Cancer Proliferation by Binding to HuR and Stabilizing YWHAZ Expression Through the AKT/GSK-3b Pathway. Front Oncol. 2021 Jun 14;11:645832.
[4]. Down-regulation of estrogen-related receptor alpha (ERRα) inhibits gastric cancer cell migration and invasion in vitro and in vivo. Aging (Albany NY). 2021 Feb 11;13(4):5845-5857.
[5]. THBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection. Aging (Albany NY). 2021 Aug 14;13(15):19375-19396.
[6]. ATP5B promotes the metastasis and growth of gastric cancer by activating the FAK/AKT/MMP2 pathway. FASEB J. 2021 Apr;35(4):e20649.
[7]. LRG1 mediated by ATF3 promotes growth and angiogenesis of gastric cancer by regulating the SRC/STAT3/VEGFA pathway. Gastric Cancer. 2022 May;25(3):527-541.
[8]. CHREBP suppresses gastric cancer progression via the cyclin D1-Rb-E2F1 pathway. Cell Death Discov. 2022 Jun 29;8(1):300.
[9]. Downregulated Reprimo by LINC00467 participates in the growth and metastasis of gastric cancer. Bioengineered. 2022 May;13(5):11893-11906.
[10]. Histidine-rich calcium binding protein promotes gastric cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition through Raf/MEK/ERK signaling. J Cancer. 2022 Jan 4;13(4):1073-1085.
肺癌
1
IF:12.658 J Exp Clin Cancer Res
标题:Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells(2022年,基因机制 肺腺癌)
作者及单位:中国科学院近代物理研究所 张宏
细胞:A549(人非小细胞肺癌细胞)
和元生物服务:LV-shRPS27a/LV-NC(干扰)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785590/pdf/13046_2021_Article_2230.pdf
2
IF:10.75 Int J Biol Sci
标题:PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer(2022年,凋亡基因机制)
作者及单位:广州医科大学第一附属医院 周承志
细胞:H1299(人非小细胞肺癌细胞)
和元生物服务:LV-shPPDPF/LV-NC/Ad-Cre(干扰)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692159/pdf/ijbsv18p0214.pdf
3
IF:9.685 Cell Death Dis
标题:Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR(2022年,耐药研究 基因机制)
作者及单位:兰州大学生命科学学院 牟凌云
细胞:NCI-H1944/NCI-H1975/NCI-H226/A549/HCC827(人非小细胞肺癌细胞)
和元生物服务:LV-shNK1R/LV-NK1R/LV-NC(干扰 过表达)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748918/pdf/41419_2021_Article_4485.pdf
4
IF:9.756 Cancer Lett
标题:Repression of the AURKA-CXCL5 axis induces autophagic cell death and promotes radiosensitivity in non-small-cell lung cancer(2021年,自噬)
作者及单位:华中科技大学同济医学院联合医院肿瘤中心 程晶
细胞:A549(人非小细胞肺癌细胞)
和元生物服务:LV-shAURKA-2 /LV- LC3B/LV-NC(干扰 过表达)
原文链接:https://sci-hub.st/10.1016/j.canlet.2021.03.028
更多客户文章:
[1]. Exosomal miR-375-3p breaks vascular barrier and promotes small cell lung cancer metastasis by targeting claudin-1. Transl Lung Cancer Res. 2021 Jul;10(7):3155-3172.
[2]. XMD-17-51 Inhibits DCLK1 Kinase and Prevents Lung Cancer Progression. Front Pharmacol. 2021 Mar 8;12:603453.
[3]. Z-guggulsterone induces PD-L1 upregulation partly mediated by FXR, Akt and Erk1/2 signaling pathways in non-small cell lung cancer. Int Immunopharmacol. 2021 Apr;93:107395.
[4]. USP35 mitigates endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer. Mol Oncol. 2022 Apr;16(7):1572-1590.
[5]. Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice.
Cell Death Discov. 2022 Jan 14;8(1):26.
[6]. He-Chan Pian inhibits the metastasis of non-small cell lung cancer via the miR-205-5p-mediated regulation of the GREM1/Rap1 signaling pathway. Phytomedicine. 2022 Jan;94:153821.
[7]. CircRNA6783 Inhibits Cell Proliferation and Promotes Apoptosis in Lung Adenocarcinoma. Cancer Manag Res. 2022 Mar 22;14:1229-1236.
乳腺癌
1
IF: 14.903 Acta Pharmaceutica Sinica B
标题:Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer(2022年,自噬 基因机制)
作者及单位:南京大学生命科学学院 沈燕
细胞:SUM-1315(人乳腺癌细胞)
和元生物服务:LV-SERCA2/LV-NC(过表达)
原文链接:
https://reader.elsevier.com/reader/sd/pii/S2211383522002155?token=A781CF88537AA221CD2FE0BC26E6A798AD864E1EF5424BA22ED42F127A929446E9D4628DC48061AFB70658AF1C41EEB8&originRegion=eu-west-1&originCreation=20221019100035
2
IF:12.658 J Exp Clin Cancer Res
标题:Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway(2022年,基因机制)
作者及单位:南京医科大学 丁强
细胞:MDA-MB-231/SUM1315(人乳腺癌细胞)
和元生物服务:LV-KIF23/LV-FOXM1/LV-NC(过表达)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077852/pdf/13046_2022_Article_2373.pdf
3
IF:9.685 Cell Death Dis
标题:Activation of CD44 signaling in leader cells induced by tumor-associated macrophages drives collective detachment in luminal breast carcinomas(2022年,肿瘤相关巨噬细胞 信号通路)
作者及单位:上海交通大学附属第六人民医院 高峰
细胞:MCF7/T47D(人乳腺癌/乳腺导管癌细胞)
和元生物服务:LV-shCD44/LV-NC(干扰)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184589/pdf/41419_2022_Article_4986.pdf
4
IF:10.183 Mol Ther Nucleic Acids
标题:SMC1Aregulated by KIAA1429 in m6A-independent manner promotes EMT progress in breast cancer(2021年,肿瘤转移)
作者及单位:南京医科大学附属第一医院 丁强
细胞:SUM-1315/ZR-75-1(人乳腺癌细胞/人乳导管癌细胞)
和元生物服务:LV-shKIAA1429/LV-KIAA1429/LV-NC/ADV-KIAA1429-mut/ADV-NC(干扰 过表达)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683616/pdf/main.pdf
5
IF:9.685 Cell Death Dis
标题:A novel long non-coding RNA AC073352.1 promotes metastasis
and angiogenesis via interacting with YBX1 in breast cancer(2021年,长链非编码)
作者及单位:山东大学齐鲁医学院 王传新
细胞:MDA-MB-231/MDA-MB-468(人乳腺癌细胞)
和元生物服务:LV-shC073352.1 c/LV-C073352.1 c/LV-NC(干扰 过表达)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254808/pdf/41419_2021_Article_3943.pdf
更多客户文章:
[1]. Hypoxia-Mediated Complement 1q Binding Protein Regulates Metastasis and Chemoresistance in Triple-Negative Breast Cancer and Modulates the PKC-NF-kB-VCAM-1 Signaling Pathway. Front Cell Dev Biol. 2021 Feb 23;9:607142.
[2]. The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells. Mol Biol Rep. 2022 Feb;49(2):1171-1179.
[3]. Transmembrane 4L Six Family Member 1 Suppresses Hormone Receptor-–Positive, HER2-Negative Breast Cancer Cell Proliferation. Front Pharmacol. 2022 Jan 27;13:770993.
[4]. miR‑107 is involved in the regulation of NEDD9‑mediated invasion and metastasis in breast cancer. BMC Cancer. 2022 May 12;22(1):533.
胰腺癌
1
IF:17.694 Nat Commun
标题:LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling(2021年,肿瘤代谢 lncRNA)
作者及单位:中山大学 林东昕/郑健
细胞:PANC-1/SW1990(人胰腺癌细胞)
和元生物服务:pLenti-U6-spgRNA/v2.0-CMV-sfGFP-P2A-3Flag-spCas9(敲除)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219694/pdf/41467_2021_Article_23904.pdf
2
IF: 12.067 Cell Death Differ
标题:YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect(2021年,代谢 糖酵解)
作者及单位:上海交通大学附属第九人民医院 孟祥军
细胞:Panc-1/MiaPaCa-2(人胰腺癌细胞)
和元生物服务:LV-miR-30d/LV-NC(过表达)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563797/pdf/41418_2021_Article_804.pdf
3
IF:8.756 Oncogene
标题:Roundabout homolog 1 inhibits proliferation via the YY1-ROBO1-CCNA2-CDK2 axis in human pancreatic cancer(2021年,基因机制)
作者及单位:南京医科大学附属第一医院 蒋奎荣
细胞:MiaPaca-2/PANC-1(人胰腺癌细胞)
和元生物服务:LV-shROBO1/LV-ROBO1/LV-NC(干扰 过表达)
原文链接:
https://sci-hub.st/10.1038/s41388-021-01741-5
4
IF:10.75 Int J Biol Sci
标题:Enhanced pentose phosphate pathway activity promotes pancreatic ductal adenocarcinoma progression via activating YAP/MMP1 axis under chronic(2022年,代谢重编程)
作者及单位:重庆医科大学第二附属医院 周志航
细胞:PANC-1(人胰腺癌细胞)
和元生物服务:LV-shMMP1/LV-NC(干扰)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990471/pdf/ijbsv18p2304.pdf
5
IF:9.685 Cell Death Dis
标题:A novel long non-coding RNA AC073352.1 promotes metastasis
and angiogenesis via interacting with YBX1 in breast cancer(2021年,长链非编码)
作者及单位:山东大学齐鲁医学院 王传新
细胞:MDA-MB-231/MDA-MB-468(人乳腺癌细胞)
和元生物服务:LV-shC073352.1 c/LV-C073352.1 c/LV-NC(干扰 过表达)
原文链接:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254808/pdf/41419_2021_Article_3943.pdf
更多客户文章:
[1]. Zinc finger protein 91 accelerates tumour progression by activating β-catenin signalling in pancreatic cancer. Cell Prolif. 2021 May;54(5):e13031.
[2]. RNA m6A Demethylase ALKBH5 Protects Against Pancreatic Ductal Adenocarcinoma via Targeting Regulators of Iron Metabolism. Front Cell Dev Biol. 2021 Oct 18;9:724282.
[3]. ELK3 Mediated by ZEB1 Facilitates the Growth and Metastasis of Pancreatic Carcinoma by Activating the Wnt/b-Catenin Pathway. Front Cell Dev Biol. 2021 Aug 2;9:700192..
[4]. Long noncoding RNA SOX2OT promotes pancreatic cancer cell migration and invasion through destabilizing FUS protein via ubiquitination. Cell Death Discov. 2021 Sep 22;7(1):261.
[5]. A Novel Sushi-IL15-PD1 CAR-NK92 Cell Line With Enhanced and PD-L1 Targeted Cytotoxicity Against Pancreatic Cancer Cells. Front Oncol. 2022 Mar 22;12:726985.
载体种类丰富|质量稳定|周期短
和元生物拥有10万+的病毒包装经验/4.6万+病毒载体库,包装GMP级别的病毒质粒。
定制慢病毒:涵盖过表达/干扰、CRISPR/Cas9、Cumate诱导表达系统、Tet-on/off系统、Cre-loxp系统等;
现货慢病毒:涵盖CRISPR/Cas9敲除或激活文库、自噬单标或双标、萤光素酶等产品。
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